Japanese Center for the Validation of Alternative Methods
Office : New Testing Method Assessment, Division of Pharmacology,
National Biological Safety Research Center (NBSRC),
National Institute of Health Sciences (NIHS)

JaCVAM Activities

2011 Academic activities

-- 2012 　→ 2011 　<Articles> <Presentations, Speeches> 　-- 2010 　-- 2009 　-- 2008 　-- 2007 　-- 2006

Articles

-- 2011

• Pfuhler S, Fellows M, van Benthem J, Corvi R, Curren R, Dearfield K, Fowler P, Frötschl R, Elhajouji A, Le Hégarat L, Kasamatsu T, Kojima H, Ouédraogo G, Scott A, Speit G: In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop, Mutat. Res., 723(2):101-7 (2011)
• Kano, S., Todo, H., Furui, K., Sugie, K., Tokudome, Y., Hashimoto, F., Kojima, H., Sugibayashi, K.: Comparison of Several Reconstructed Cultured Human Skin Models by Microscopic Observation: Their Usefulness as an Alternative Membrane for Skin in Drug Permeation Experiments, Altern. Animal Test. EXperiment, 16(2): 51-58（2011）

Presentations, Speeches

-- 2011

• Kojima, H.: The Japanese Center for the Validation of Alternative Methods (JaCVAM): Recent ICATM contributions and Future Plans, Information Session: The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools, 50th Annual SOT meeting, Washington D.C.(2011)
• Kojima, H. and Hojyo, M.: Optimal conditions for performance of the comet assay using a three-dimensional human epidermal model, 50th Annual SOT meeting, Washington D.C.(2011)
• Casey, W., Ceger, P., Deal, FH., Allen, D., Clark, G., Pazos, P., Grignard, E., de Lange, J., Bremer, S., Nakamura, M., Kojima, H., Ono, A., Stokes, WS.: Final Results of an International Validation Study of an In Vitro ER TA Test Method in BG-1 cells, 50th Annual SOT meeting, Washington D.C.(2011)
• Deal, FH., Casey, W., Ceger, P., Allen, D., Yang, C., Nakamura, M., Kojima, H., Ono, A., Yoon, HJ., Ha, SY., Stokes, WS: International Validation Study of an In Vitro Cell Proliferation Test Method for Screening Potential Estrogenic Agonists and Antagonists in MCF-7 cells, 50th Annual SOT meeting, Washington D.C.(2011)
• Kulpa-Eddy, J., McFarland, R., Isbrucker, R., Halder, M., Kojima, H., Jones, B.,Johnson, NW., Allen, D., Lipscomb, E., Morefield, S., Casey, W., Stokes, WS.: International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing, 50th Annual SOT meeting, Washington D.C.(2011)
• Kojima,H.: Update of skin equivalent and its regulatory use, BIT's 4th Aunal World Congress of Industrial Biotechnology-2011, Dalin, China（2011.4）
• Yamamoto, N., Hirano, K. , Sumitomo, M., Yamashita, H., Nakamura ,M., Hara , K., Tanikawa , A., Horiguchi, M., Taniguchi K. and Kojima, H.：Generation and Analysis of a New Immortalized Human Corneal Epithelium Cell Line, 2011 In Vitro Biology Meeting, Raleigh, North Carolina, USA(2011.6)
• Kojima, H.: Current and future of correlation with japan and Korea on alternative to animal experiments, 8th　Congress of Korean Society for Alternative to Animal Experiments, Korea (2011.7)
• Kojima, H. : Section II-11　The International Cooperation on Alternative Test Methods (ICATM), JaCVAM, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Uno, Y., Kojima, H., Hayashi, M.: In vivo Comet assay: update on the ongoing international validation study coordinated by JaCVAM, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Kojima ,H., Yamakage, K., Oba, S., Tsuge, H., Aoki, M.: Preliminary study of the revision of Japanese Pharmacopoeia test for rubber closure for aqueous infusions, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Ono, A., Takeyoshi , M., Bremer, S., Jacobs, M., Laws, S., Sozu, T. and Kojima, H.: Results of the validation study of the stably-transfected estrogen receptor alpha transcriptional activation antagonist assay using the HeLa9903 cell line, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Hayashi, K., Hayashi, T., Sakaguchi, M., Watanabe, S. and Kojima, H.: Inter-laboratory phase II validation study of in vitro eye irritation test; Short Time Exposure (STE) test, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Nakamura, M., Suzuki , T., Shinoda, S., Kato, M. and Kojima, H.: Additional validation of alternative skin irritation test method using LabCyte EPI-MODEL24 of cultured skin, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• McFarland, R., Kulpa-Eddy, J., Isbrucker, R., Halder, M., Kojima, H., Johnson, N., Jones, B., Allen, D., Casey, W. and Stokes, W.: International workshop　on　alternative　methods　to　reduce,　refine,　and　replace　the　use　of　animals　in　human vaccine　potency and safety testing, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Kulpa-Eddy , J., McFarland, R., Isbrucker, R., Halder, M., Kojima, H., Johnson, N., Jones, B., Allen, D., Casey, W. and Stokes, W.: International workshop　on　alternative　methods　to　reduce,　refine,　and　replace　the　use　of　animals　in　veterinary vaccine　potency and safety testing, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Stephens, M., Kojima, H., Patlewicz-Tier, G., Spielmann H. and Telley, L.: AltTox.org: communication platform for 21st century toxicology, 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal, Canada (2011.8)
• Kojima, H.: Necessity of validation study of new or updated test methods for hazard assessment, Workshop on Validation of 3T3 Neutral Red Uptake Phototoxic Test, Guangzhou, China (2011.11)