Japanese Center for the Validation of Alternative Methods
Office : New Testing Method Assessment, Division of Pharmacology,
National Biological Safety Research Center (NBSRC),
National Institute of Health Sciences (NIHS)
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Skin irritation test
| 04-001／In-vitro tests for skin irritation (EPISKIN) |
| Summary | Three-dimensional human skin model assays consisted in applying the test chemicals to the surface of the skin for 15 minutes, followed by a post-treatment incubation period of 42 hours, and the subsequent assessment of their effects on cell viability by using the MTT assay. | ||||||||||||
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| Documents |
[Validation study] STATEMENT ON THE VALIDITY OF IN-VITRO TESTS FOR SKIN IRRITATION 04_001_07.pdf (829 KB)  /European Center for the Validation of Alternative Methods (ECVAM) [JaCVAM Statement] JaCVAM statement on the in-vitro tests for skin irritation 04_001_08.pdf (599 KB) /National Institute of Health Sciences (NIHS) [OECD Test Guideline] Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method http://titania.sourceoecd.org/vl=6337078/cl=14/nw=1/rpsv/ij/oecdjournals/1607310x/v1n4/s59/p1 |
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